Anchorage Digital — America's Only Federally Chartered Crypto Bank
Anchorage Digital Bank received the only federal OCC national bank charter for a crypto institution in January 2021, holding $50B+ in custody for institutional clients including banks, hedge funds, and sovereign wealth funds.
BitGo — The Qualified Custodian for Digital Assets
BitGo is the oldest dedicated crypto custodian, holding $64B+ in assets for 1,500+ institutional clients, and processes over 20% of global Bitcoin transaction volume through client wallets.
BNY Mellon Digital Assets — The World's Largest Custodian Goes On-Chain
BNY Mellon, custodian of $46.7T in assets, became the first US bank approved by both the SEC and NY DFS to hold Bitcoin and Ethereum for institutional clients in October 2022.
Coinbase Prime — Institutional Access to the Coinbase Infrastructure
Coinbase Prime provides institutional custody, trading, and staking through a NYDFS-chartered trust company, serving as custodian for BlackRock's iShares Bitcoin ETF and holding $400B+ in total platform assets.
Copper — Institutional Custody with ClearLoop Settlement
Copper provides MPC-based institutional custody for $30B+ in assets and operates ClearLoop, a settlement network enabling institutional traders to settle exchange trades without moving assets off custody — directly addressing the counterparty risk exposed by the FTX collapse.
Multi-Party Computation (MPC) for Custody
Multi-Party Computation (MPC) is a cryptographic technique that splits a private key into shares distributed across multiple parties, enabling institutional-grade digital asset custody without any single point of key compromise — the dominant security architecture for regulated digital asset custodians.
Qualified Custodian
A Qualified Custodian is an institution legally authorized to hold client assets on behalf of SEC-registered investment advisers — a requirement that historically excluded most crypto-native firms but is expanding to include digital asset custodians following SAB 121's reversal and OCC charter approvals.
State Street Digital — Custody, Funds, and the Institutional Build-Out
State Street Digital, launched in 2021 with $43.7T in assets under custody, is building institutional blockchain infrastructure across custody, fund administration, and digital transfer agency for 70+ clients.